(b) intracutaneous injection into normal guinea pigs without admixture with antitoxin, and 1/50 of one test dose must not cause, and 1/25 of one test dose must cause, a definite local reaction of the type known as the “positive Schick reaction”.Ĭ.04.144 The human test dose of diphtheria toxin for Schick test, when fresh toxin containing no preservative is used, shall be determined by (a) intracutaneous injection into normal guinea pigs in mixtures with different proportions of diphtheria antitoxin, and one test dose mixed with 1/750 or more of a unit of antitoxin must cause no local reaction but mixed with 1/1,250 or less of a unit of antitoxin must cause a definite local reaction of the type known as the “positive Schick reaction” and

(b) sterile diphtheria toxin heated at a temperature of 95☌ for five minutes.Ĭ.04.143 The human test dose of diphtheria toxin for Schick test, when aged toxin containing a preservative is used, shall be determined by (c) diphtheria toxin for Schick test with control.Ĭ.04.141 Diphtheria toxin for Schick test shall be sterile diluted diphtheria toxin stabilized by an acceptable method.Ĭ.04.142 Schick control shall be suitably diluted Toxins, Toxoids Schick Test ReagentsĬ.04.140 Schick test reagents for the diagnosis of susceptibility to diphtheria shall be

© 2018 British Small Animal Veterinary Association.PART C Drugs (continued) DIVISION 4 (continued) Poliomyelitis VaccineĬ.04.122 Poliomyelitis vaccine shall be an aqueous suspension of killed poliomyelitis viruses, Types I, II, and III.Ĭ.04.123 Poliomyelitis vaccine shall be prepared in acceptable tissue culture medium from strains of poliomyelitis virus proven capable of producing vaccine of acceptable potency.Ĭ.04.124 Poliomyelitis vaccine in its final form shall contain not more than 0.35 milligram per millilitre of total nitrogen, nor more than one part per million of animal serum.Ĭ.04.125 No person shall sell poliomyelitis vaccine unless it has been tested by an acceptable method for potency and safety and when so tested it shall be safe and of acceptable potency.Ĭ.04.126 The outer label shall carry a statement of any antibiotic present in the vaccine.Ĭ.04.127 The expiration date of the poliomyelitis vaccine shall be not later than 12 months after the date of the last satisfactory potency test unless evidence, satisfactory to the Minister, is presented that a longer period is appropriate.Ĭ.04.137 Bacteriophage shall be a virus preparation with specific lytic action against micro-organisms actually or potentially pathogenic.Ĭ.04.138 The expiration date of bacteriophage shall be not later than 12 months after the date of manufacture or the date of issue. Hair and saliva testing should not be used to diagnose allergies and is not a substitute for veterinary-directed allergy evaluation and diagnostics.

Test-retest reproducibility was poor to slight. The distribution of test results from samples obtained from allergic, non-allergic or fake dogs was not different from that expected due to random chance. Statistical analyses were performed to determine whether the response distribution differed significantly between dogs, using the Pearson chi-square coefficient, as well as to determine test-retest reliability by calculating Cohen's kappa for each allergen. The company performed testing for 128 food and environmental allergens. Five fake fur samples and water were also submitted to determine whether the test could differentiate between a real dog and toy animal. Ten fur and saliva samples were submitted from a known allergic dog and a normal, non-allergic dog. We examined one such hair and saliva allergy test to determine whether it could reliably differentiate between a normal dog and an allergic dog, and to examine test repeatability. Several companies offer saliva and/or hair tests for food and environmental allergies in companion animals, but provide no validation of test accuracy.

Does schick test on animals